This study was designed to prove the probable effect of oral treatment (combination of tamsulosin with potassium citrate) on serum xanthine oxidoreductases and oxidative stress levels for patients with nephrolithiasis. A total of 55 newly diagnosed nephrolithiasis patients (P1 group) were involved in this study matched with 30 apparently healthy volunteers (C group); 22 of the patients (P2 group) were followed after treatment. Blood urea, creatinine, uric acid, total serum protein (TSP), and albumin were measured by using Abbott c400 analyzer. Colorimetric methods were used to detect total antioxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), xanthine oxidoreductases enzymes (xanthine oxidase (XO) and xanthine dehydrogenase (XDH)) and other biochemical parameters. One-way ANOVA test was used for data analysis. For P1 group in comparison to that of C and P2 groups, the observed results were as follows: significant increases were observed in serum urea, creatinine, MDA, TOS, TAS, OSI, XO, and UA, p=0.007, p=0.001, p=0.000, p=0.000, p=0.000, p=0.002, p=0.039 respectively, while significant decreases were indicated XDH, TSP, and albumin, p=0.000, p=0.001, p=0.001 respectively. Meanwhile, the measured parameters were exhibited a good alteration after treatment (TOS and TAS were significantly decreased, while TSP and albumin were slightly increased). The present study suggests that the used treatment success in balancing the oxidative stress of nephrolithiasis patients by decreasing the oxidants and increasing the antioxidant parameters leading to prevent the renal damage.