The valuation and choice of unsuitable open source software in electronic medical record (OSS-EMR) groups negatively affects the functions of organization and business processes. This study provides an insight into the assessment and choice of OSS-EMR groups in two ways. Firstly, quality characteristics are determined to evaluate OSS-EMR sets according to current frameworks and quality models. Secondly, the capabilities of appropriate choose methods for resolving OSS-EMR groups problems are discussed on the basis of Multi-criteria assessment and select issues are considered for choosing the best OSS-EMR. The obtained results can be attributed to the following:(1) quality characteristics considered for the evaluation of OSS-EMR groups; (2) the gap in the assessment criteria used in EMR and other issues; and Multi-Criteria or Multi-Attribute Decision Making techniques used in framework for evaluating and selecting OSS in health informatics as part of a recommended solution.