Vernonia amygdalina is a common plant reported to have several health benefits. This study investigated the dose dependent hypolipidemic potentials of the leaf extracts, following Triton WR 1339 induced hyperlipidemia. Adult male albino rats (average weight 185 ± 0.7 g) were pretreated with the ethyl acetate extract at 0, 100, 200 and 400 mg/kg body weight for seven (7) days after which the hyperlipidemia was induced with Triton WR 1339 (200 mg/kg body weight). The serum and liver of the animals were then assayed for; total cholesterol, triglycerides, HDL (high density lipoprotein) and LDL (low density lipoprotein). Histopathological investigation was carried out in the liver of all experimental animals. The result showed that pretreatment with ethyl acetate extract of V. amygdalina elicited a significant dose dependent (P<0.05) decline in Triton WR 1339 invoked increase in Total cholesterol and triglycerides concentration. Similarly, there was a significant dose dependent reduction in the levels of LDL in the pretreated group when compared to Triton WR 1339 control group. Conversely, significant (P<0.05) dose dependent increase was observed in HDL levels in the pretreated group when compared to the Triton group. It could be inferred from the results that V. amygdalina reduces the risk of diseases caused by hyperlipidemia

Garcinia kola has been confirmed for spermatogenic and tissue enhancing effect of testis in male wistar rats. This study was carried out to investigate the histological effect of ethanolic extract of Garcinia kola on Lead II oxide induced testicular damage. Thirty five (35) adult male wistar rats were randomly selected into seven (7) groups n=5. Group A received 0.5 ml saline solution, Group B received 100 mg/kg of Garcinia kola extract only, Group C received 5 mg/kg of Lead II oxide only, Group D 1 received 100 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group D 2 received 200 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group E received 500 mg/kg of vitamin E only and Group F received 500 mg/kg of vitamin E and 5 mg/kg Lead II oxide. Administration was done orogastrically daily for 2 weeks, animals were sacrificed 24 hours after the last administration by cervical dislocation and the testes excised following abdominal incision for histological observation using H/E stain. Slight degeneration of the germinal epithelium of the seminiferous tubule and abnormal widening of the interstitial space involving loss of Leydig were observed following the administration of Lead II oxide. However, Improvements in the testicular architecture were noticed in the rats treated with the Garcinia kola and the Vitamin E respectively thus histological integrity maintained.

Background: Cadmium (Cd) has been reported to cause distinct neurotoxic effects in adult and newborn animals. This study was designed to investigate some of the effects caused by cadmium on the lateral geniculate body of adult male wistar rats and the ameliorative properties of antioxidants present in Moringa oleifera seed oil and walnut oil extracts. Methods: Seven groups of fi ve animals each were used in this experiment. Group A received 3 ml of 0.9% normal saline; group B received 2.5 mg/kg bw of 3CdSO 4 .8H 2 O, group C received 5 mg/kg bw vitamin C & 6 mg/kg bw vitamin E, group D received 5 mg/kg bw vitamin C & 6cmg/kg bw vitamin E + 2.5mg/kg bw Cd, group E received 2.5 mg/kg bw Cd + 4 mg/kg bw Moringa oleifera Oil, group F received 2.5 mg/kg bw Cd + 4 mg/kg bw walnut oil, while group G received 2.5 mg/kg bw Cd + 2 mg/kg bw walnut + 2 mg/kg bw Moringa oleifera oil concomitantly for 3 weeks, histomorphological investigations were carried out in the brain tissues. Results: Light microscopy examination revealed marked changes in the structure of the studied tissues of Cd administered animals. However, administration of vitamin C & E, walnut and Moringa oleifera seed oil was seen to counteract the changes of the measured parameters and restore the damaged tissues associated with Cd administration to appear nearly like those of the control group A. Conclusion: Walnut and Moringa oleifera seed oil administration attenuated morphological changes induced by cadmium in the lateral geniculate body of the brain of the adult male wistar rats. Research Article Histomorphological characterization of Moringa-oleifera oil and walnut oil on cadmium induced lateral geniculate body damage in adult wistar rats