This study aimed for the synthesis of new heterocyclic compounds incorporating sulfamoyl moiety suitable for use as antimicrobial agents via a versatile, readily accessible N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide (3). The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with acetylacetone or arylidenes malononitrile. Cycloaddition reaction of cyanoacetamide with salicyaldehyde furnished chromene derivatives. Diazotization of 3 with the desired diazonium chloride gave the hydrazone derivatives 13a–e. Also, the reactivity of the hydrazone towards hydrazine hydrate to give Pyrazole derivatives was studied. In addition, treatment of 3 with elemental sulfur and phenyl isothiocyanate or malononitrile furnished thiazole and thiophene derivatives respectively. Reaction of 3 with phenyl isothiocyanate and KOH in DMF afforded the intermediate salt 17 which reacted in situ with 3-(2-bromoacetyl)-2H-chromen-2-one and methyl iodide afforded the thiazole and ketene N,S-acetal derivatives respectively. Finally, reaction of 3 with carbon disulfide and 1,3-dibromopropane afforded the N-[4-(aminosulfonyl) phenyl]-2-cyano-2-(1,3-dithian-2-ylidene)acetamide product 22. All newly synthesized compounds were elucidated by considering the data of both elemental and spectral analysis. The compounds were evaluated for both their in vitro antibacterial and antifungal activities and showed promising results.

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New nanocomposite based on chitosan and acrylamide and silver nanoparticles has been prepared to produce wound dressing has superior properties as Hemostatic and antibacterial activity. Chitosan successfully grafted with acrylamide via free radical copolymerization using potassium persulphate. Four different chitosan grafted acrylamide prepared and fully characterized through nitrogen content and ATR/IR. Cs-g-PAAM partially hydrolyzed at basic condition in presence of silver nitrate in order to prepare Cs-g-PAAm-co-PAAc/Ag nanococomposite. The optimum condition for preparing homogenous and well distributed was examined using grafted polymers were characterized using TEM and UV-vis absorption. Cs:PAAm (1:1) pH 11 and 120 min showed homogenous spherical silver nanoparticles and distributed particles lying at nanosize range between 10-30 nm. SEM-EDX and XRD used to confirm binding silver to chitosan hybrid chains forming newly nanocomposite. Produced composite showed complete solubility at neutral medium condition that qualifies produced composite to be used at different medical and industrial applications.