Study of the determination of the polymorphic variants -1298A> C and -677C> T of the gene of methylenetetrahydrofolatereductase (MTHFR) in predicting the congenital pathology of the maxillofacial area. Objectives. To study the role of polymorphisms -1298A> C and -677C> T of the MTHFR folate cycle gene in the formation in patients with congenital pathology of the maxillofacial area. Methods. We analyzed the frequency distribution of genotypes and alleles according to polymorphism 1298 A> C of the MTHFR gene. We also analyzed the frequency distribution of genotypes and alleles according to polymorphism 677C> T of the MTHFR gene in a group of patients (n = 37) with congenital pathology of the maxillofacial area and control group (n = 46). Results. Genetic marker of the disease congenital pathology of the maxillofacial area is the genotype of the SS polymorphic locus 1298 A> C of the MTHFR gene. Its frequency was 13.6% against 2% in the control. In the calculation of odds ratios index following values were obtained: OR-7,32; CI95% -1.51-48.51. The results confirm the predictive value of a mutant CC genotype -1298A>C MTHFR gene as a risk of congenital disease pathology maxillofacial area. There was no statistically significant differences between patients and the control group for the distribution of frequencies of genotypes and alleles of the locus 677 C> T of the MTHFR gene. Conclusions. Genetic marker of congenital pathology of the maxillofacial area is the genotype of the SS polymorphic locus 1298 A> C of the MTHFR gene. The obtained data can be used, to predict a congenital pathology of the maxillofacial area with the purpose of treatment and prevention.

We have carried out the rehabilitation of a patient after a traumatic injury to the maxillofacial region resulting from the explosion of an electronic cigarette. The patient was treated in the Department of Maxillofacial Surgery of the Republican Children's Clinical Hospital in Ufa. A 16-year-old boy was delivered by an ambulance to the emergency department of the Republican Children's Clinical Hospital in Ufa 30 minutes after the injury. The child was hospitalized in the department of maxillofacial surgery. At stage I, primary surgical treatment was performed, reposition of the free-lying fragment of the upper jaw in the frontal section and fixation of the mucosa of the alveolar process of the upper jaw in the region of 1.3 and 2.4 teeth with vicryl 2.0. The mucosa was mobilized along the transitional fold of the upper jaw in the anterior region, placed in the region of the defect in the upper jaw, and sutured with a 5-0 Vicryl thread. After 6 months, the patient enters the II stage of surgical treatment. The cortical plates were placed in the area of the defect and fixed with titanium screws. After another 6 months, the child enters the III stage of surgical treatment - the removal of titanium screws, the installation of dental implants. Stage IV. Installation of temporary crowns of teeth. As a result of smoking a vape, a teenager received severe traumatic stress. Stage IV of complex surgical treatment was carried out. There are stages of implant prosthetics, which is quite expensive for the patient, since this treatment is not included in the List of State Guarantees. Undoubtedly, vape smoking is a very cost-effective procedure, and very harmful to health in general.