Objectives: To explore participants' views regarding clinical use of deceptive placebo (DP) and open-label placebo (OLP) treatments. Design: Qualitative thematic analysis. Methods: We conducted eight semi-structured interviews with healthy participants in an experimental trial comparing the efficacy of OLP and DP (Clinical trials n°NCT03934138).Interviewees' opinions were solicited following administration of placebos during the trial. Interviews were analysed using data-driven analysis. Results: We identified three themes. First, participants considered trust central in judging a placebo treatment to be acceptable. They expressed the importance of an implicit trust both in their health care professionals' (HCPs') competency as well as in the profession at large. A second theme was the perception of how placebo treatments might solve health problems. Acceptability of both types of placebo treatments was dependent on the perception patients had about the treatment solving their problem and/or doubts regarding the effectiveness of placebos The third theme encompassed perceived risks associated with placebo prescribing. Some