BACKGROUND: Fluorosis is intrinsic tooth discoloration which compromises esthetics depending on its severity. AIM: The aim of the study was to assess the efficiency of various treatment modalities in esthetic improvement of mild fluorosed teeth. MATERIALS AND METHODS: Four patients with 48 mild fluorosed teeth were randomly assigned to four treatment modalities (n = 12). The modalities included M1: power bleaching, M2: microabrasion and power bleaching, M3: power bleaching and resin infiltration and M4: microabrasion, power bleaching and resin infiltration. Color parameters (L, a, b) and visible color change (ΔE) were measured by spectrophotometer (VITA Easyshade®) at baseline, immediately after the treatment, after 3, 6, and 9 months. STATISTICAL ANALYSIS: Two-way ANOVA was applied to test the interaction between different variables. ANOVA repeated measures were followed by Duncan multiple range tests (DMRTs) to compare between groups. RESULTS: All the treatment modalities showed significant color change (ΔE) at all-time points compared to baseline. The highest color change was recorded in the resin infiltration treatment modalities compared to the other treatment modalities. Bleaching alone had the lowest change. CONCLUSION: Resin infiltration treatment modalities were more effective in the esthetic improvement of dental fluorosis compared to either power bleaching alone or combination of microabrasion and power bleaching.