Objectives. To compare the peri-implant crevicular fluid (PICF) biomarker levels, peri-implant status, and marginal bone level (MBL) differences of implants restored with randomly assigned nonplatform-switched (NPS) or platform-switched (PS) abutments. Methods. Ninety-four implants in 27 subjects were included in this study. Receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), interleukin-1β (IL-1β), monocyte chemotactic protein-1 (MCP-1) levels in PICF, peri-implant health, and the change in the MBL were evaluated at the time of restoration ( T 1 ) and after 12 months ( T 2 ). Results. The IL-1β levels decreased and the RANKL, OPG, and MCP-1 levels increased from T 1 to T 2 ( P < 0.05 ) in both groups. RANKL/OPG ratio at T 1 , MCP-1 levels at T 2 , and the MCP-1 change from T 1 to T 2 were lower in the PS group than in the NPS group ( P < 0.05 ). MBL change was lower ( 0.51 ± 0.31  mm) in the PS group than that ( 0.75 ± 0.29  mm) in the NPS group at T 2 ( P < 0.001 ). Peri-implant health status between the study groups was negligible. Conclusion. PS was superior to NPS regarding the preservation of MBL. Higher MCP-1 levels, altered RANKL/OPG ratio, and lower OPG levels in the NPS group could be associated with subclinical peri-implant bone remodeling.