Intracoronary injection of alginate biomaterial is feasible, safe, and effective. Our findings suggest a new percutaneous intervention to improve infarct repair and prevent adverse remodeling after reperfused MI.

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Tissue engineering entails the in vitro or in vivo generation of replacement tissues from cells with the aid of supporting scaffolds and stimulating biomolecules, in order to provide biological substitutes for restoration and maintenance of human tissue functions. In this review, we summarize the main classes of degradable polymeric scaffolds, natural and synthetic ones, and the evolution made in this field from adaptation of materials in clinical use to the fabrication of “designer” scaffolds.