Objectives:The objective of this study is to examine the benefit of an intra-articular platelet-rich plasma (PRP) injection and to compare this with arthrocentesis in Patients with Temporomandibular Disc Displacement with Reduction. Subjects and Methods: Twenty four patients who did not respond to conservative treatment of anterior disc displacement with reduction were included in this study. They were randomly allocated to one of two study arms: the 'intervention' group who treated with intra articular PRP injection or the control group who treated with Arthrocentesis. Results: In this study, both groups showed significant improvement in TMJ pain, maximum mouth opening (MMO) and clicking 2 weeks after treatment that maintained thereafter. Conclusion: It is possible to conclude that intra-articular PRP injection was equivalent to arthrocentesis regarding reduction of TMJ pain with more beneficial effects of arthrocentesis on MMO and TMJ sound.