For Nigeria to attain the goal of becoming one of the twenty (20) largest economies by the year 2030, the life expectancy of her citizens must be robust. This study reveals the relationship that exists between Global Life Expectancies (GLE) and some of its major predictors such as Gross Domestic Products (GDP) per capita, Electricity Consumption (ECM) per capita, and Access to Safe Water (ASW), Infant Mortality Rate (IMR), Maternal Mortality Rate (MMR) and Acquired Immune Deficiency Syndrome (AIDS) reported cases with the aim of formulating an appropriate model for measuring such relationship. Using the Ordinary Least Squares regression analysis, it is observed that the determinants contribute most significantly to the growth of life expectancies. The multiple regression analysis reveals highly significant and negatively linear relationship between life expectancy and maternal mortality rate with a significant and positive association with Gross Domestic Product per capita and access to safe water.