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Terpestacin, a new antibiotic which inhibits syncytium formation, was isolated from Arthrinium sp. FA1744(ATCC74132). The structure of terpestacin was elucidated as a bicyclic sesterterpene on the basis of spectroscopic data and chemical derivatization.

Pradimicins A, B and C specify novel antibiotics produced by Actinomadura hibisca No. PI 57-2 (ATCC53557) possessing potent and broad antifungal activity in vivo. They showed moderate in vitro antifungal activity against a wide variety of fungi and yeasts including clinically important pathogens, and were highly effective in systemic infection with Candida albicans in mice after iv and im administrations. Pradimicin Ashowed in vivo therapeutic activity against C. albicans, Cryptococcus neoformans and Aspergillus fumigatus in both normal and immunocompromizedmice. 5-Fluorocytosine-and azole-resistant C. albicans strains were susceptible to pradimicin A. This antibiotic also demonstrated therapeutic efficacy against lung candidiasis and aspergillosis, vaginal candidiasis and skin Trichophyton mentagrophytes infection in mice with iv or topical treatment. The LD50values after a single iv or im administration were 120mg/kg and more than 400mg/kg, respectively. Against various cultured mammalian cells, pradimicin A was noncytotoxic at 100 or 500 Mg/ml, and showed potent anti-influenza virus activity with an IC50 value of 6.8 jUg/ml.

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