As pathogens in recent times have developed resistance to the existing antibiotics, the demand for new and more effective antimicrobial agents is a continuous phenomenon. The study involves the synthesis of schiff base from 5-bromo-salicylaldehyde and para-toluidine.The synthesized compounds (5-Bromo -Salicylaldehyde and the Schiff base-N-(5-bromo-2-hydroxybenzylidene) Para-toluidine) were evaluated for antimicrobial activities against different bacteria strains using the agar well diffusion method. The 5-bromosalicylaldehyde and its Schiff base indicated dose dependent activity as concentration increases from 125mg/ml to 1000mg/ml and inhibitory zones were found to increase mostly for Escherichia coli. The two compounds synthesized have indicated high antimicrobial activities on the selected germs and as such can be a drug precursor to microbial infections with further research.

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