A method is described for the assay of trisulfapyrimidines tablets and trisulfapyrimidines oral suspension. Total sulfonamides are measured colorimetrically by the Bratton-Marshall procedure, and sulfadiazine is quantitated directly by means of its specific reaction with thiobarbituric acid. Sulfamethazine is separated from its homologs by column partition chromatography and is determined by ultraviolet spectrophotometry. When applied to commercial samples of trisulfapyrimidines tablets and oral suspensions, this hybrid method yields data that are consistent with assays of the same samples by the official nitrite titration method.
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