A study of the production of citrinin by Aspergillus niceus and Penicillium citrinum Thom is described. Plots of citrinin production cs. time show that the A. niceus strain investigated produces a higher yield of the antibiotic than does the Penicillium sp. A stepwise chemical degradation of citrinin which is readily adaptable to radioactive tracer techniques is reported. The process involves the degradation of this substance to the known 3-(2-methyl-3,5-dimethoxyphenyl)-2-butanone which is then degraded further by two pathways. One method leads through the ozonizáis X X.ecent years have seen the widespread acceptance of the polyacetate hypothesis (Birch, 1957;
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