In the present patient, parenteral antibiotics and daily steroids, colchicine, and oral minocycline had failed to halt the progression of ulcers. However, dexamethasone pulse therapy resulted in complete healing without sequelae and also proved cost-effective.
The male predilection documented by us was contrary to most previous studies. We found split-thickness skin graft to be a useful option in resistant cases. More prospective studies may enable the formulation of better diagnostic criteria for pyoderma gangrenosum and improve its management.
<p class="abstract"><strong>Background:</strong> Erythroderma is a generalised inflammatory disorder of skin manifesting with erythema and scaling affecting more than 90% of the skin surface. Several studies have highlighted the importance of biopsy in the diagnosis and management of erythroderma, while some others have found it to be of limited use.</p><p class="abstract"><strong>Methods:</strong> Thirty-six patients with erythroderma were enrolled in the study and a detailed history, clinical examination and relevant investigations including skin biopsy was done to find out the etiology.<strong></strong></p><p class="abstract"><strong>Results:</strong> Pre-existing dermatoses were the predominant cause (84%) contributed equally by psoriasis (42%) and eczemas (42%) and clinicopathologic correlation could be obtained in 30.55% of cases.</p><p><strong>Conclusions:</strong> Our study showed that skin biopsy remains a valuable tool in the diagnosis of erythroderma.</p>
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