In present study two medicated soaps namely Pharmaderm and Micoderme and herbal soap Morinda formulated with fat extracted from leaves of Morinda morindoides (Rubiaceae) were investigated for their antimicrobial activities against some clinical strains for skin.diseases. The purpose of this study was to verify and compare their antimicrobial effectiveness. Agar broth dilution method with Sabouraud and Mueller-Hinton at serial concentrations of soaps ranging from 62.50 to 3.9 mg/ml and agar plate method were used to determine antimicrobial parameters. All strains tested were inhibited significantly (p < 0.05) by different types of soaps with minimal fungicidal concentration (MFC) ranging from 62.50 -7.81 mg/ml and minimal bactericidal concentration (MBC) between 31.25 -7.81 mg/ml. Soap Micoderme exhibited highest antimicrobial effectiveness with MFC varying from 7.81 to 31.25 mg/ml and MBC of 15.62 mg/ml. Soaps Morinda and Pharmaderm showed similar antibacterial activities with MBC of 31.25 mg/ml. Soap Morinda with MFC of 31.25 mg/ml was more effectiveness than soap Pharmaderm (MFC of 62.50 mg/ml) against all fungi. T. mentagrophytes was most sensitive fungi whereas C. albicans was least strain in presence of tested soaps. S. aureus was the most resistant among testing bacteria. This study demonstrated that hence buttressing the information written on two medicated soaps labels they possess antimicrobial activity and fat of M. morindoides incorporated at 10 % on basic soap formulation gave an effective antimicrobial power to soap Morinda. Further investigation was to clarify the phytochemical groups of herbal fat responsible for antimicrobial power of soap Morinda.