No abstract

No abstract

No abstract

We have conducted a modified double-blind study on the effect of human chorionic gonadotropin (hCG), gonadotropin releasing hormone (GnRH) and placebo on bilateral and unilateral maldescended testes. One hundred and fifty-five boys with bilateral and 88 boys with unilateral cryptorchidism fulfilled the inclusion criteria and completed the treatment protocol. The boys were between 1 and 13 years of age. hCG was administered as intramuscular injections twice weekly for 3 weeks. GnRH and placebo were given intranasally. hCG was superior to GnRH and placebo in the treatment of bilateral maldescended testes (p = 0.0009). Both testes descended in 25% of the boys following treatment with hCG, and improvement in the position of the testes was obtained in a further 25 % of the cases. hCG administration resulted in complete testicular descent in 14% of boys with unilateral cryptorchidism compared with 3 and 0% after placebo and GnRH, respectively (p = 0.07). The testis had moved to a more distal position in 46 % of the boys treated with hCG. There was no significant difference between the treatment groups with regard to age or initial position of the testes. We conclude that a success rate of 25% justifies the use of hCG in the treatment of maldescended testes, whereas the study did not support a general use of GnRH administered intranasally.

In den friiher mitgcteiltcn Versuchsrcihen (1938, 11, 111 u. IV) war die Arbeitsintcnsitiit in allen Versuchen etwa I 100 kgm Ivlin. und die 0,-Aufnahme lag zwischen etwa 2 . 5 und 2.9 Litcr/Min. Die drei Vpn. waren schon zu Beginn der Vcrsuche erhcblich trainiert und die Versuchc wurden so eingerichtet, daB die vcrschieden groBe Fullung der Kohlchydratdepots, und dadurch wieder die prozentuale Kohlehydrat-und Fettvcrbrennupg, so weit wic moglich die einzige Variable war.In den folgenden Versuchsreihen wurdc nun dic Arbeitsintensitat stark variiert und bei annahernd gleichen Kohlehydratdepots der EinfluB der Arbeitsintensitat und damit der Stoffwechselintensitat auf die Art der Verbrennungsvorgange naher unterswht. Versuchsplan und Methodik