It has been clearly seen from building experiences and studies that lateral load effects such as earthquake load and wind load make building irregularities more obvious. Hence, it is of great importance to evaluate the regularity of the structural systems in accordance with the conditions determined by the building regulations. In this paper, irregularity effects were investigated according to Turkish Building Earthquake Regulation (TBEC) 2018. A reference building which have vertical setback irregularity were analzed under earthquake and wind loads. Etabs software were used for structural analyses. Response spectrum method were used for the seismic analysis and TS498 for Wind load analysis. Effective relative storey drift, A1 -Torsional irregularity and B2 -Soft Storey Irregularity are comparatively investigated and Irregularity values were determined.