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Graphene, an ultra-thin derivative of carbon, has hindered a lot of applications because of its unique characteristics. It was found that superb improvements on properties can be made on further by creating nanopores or nanoholes on the surface of the graphene film. Such holed graphene can be used in energy storage, fuel cells, biosensors, biochemical applications, plasmonic tweezers, etc. This is because pores can contribute toward more surface area and eventually toward transportation and storage for electron/ion, gas, and liquid. This paper is a review of graphene nanohole fabrication methods.