In the present study 10,921 canine clinical cases suspected for various cardiac diseases were screened. Ten apparently healthy dogs were selected as control group and twenty seven clinical cases of dogs with various cardiac diseases were examined. In the present study there was significant (P<0.05) decrease in haemoglobin, PCV, lymphocytes and platelet count and significant (P<0.05) increase in total leukocyte count and neutrophils in dogs with cardiac diseases. Significant (P<0.05) increase in ALT, AST and BUN levels and significant (P<0.05) decrease in total protein values were noticed in dogs with cardiac diseases. Non-significant decrease in albumin levels and no significant change in creatinine levels were observed between healthy dogs and dogs with cardiac diseases. It was concluded in initial stages of cardiac diseases till cardiac renal syndrome gets deeply involved, there won't be any clinicopathological changes like haemogram, leukogram and routine biochemical changes significant for cardiac involvement.