ChemInform Abstract About 50 title compounds are prepared and tested for their pharmacological activities. Most of the products exhibit significant hypotensive and weak to moderate diuretic, antiinflammatory and CNS depressant effects. The centrally acting hypotensive derivative (VII) (yield given in g) is found to possess the most suitable profile of hypotensive activity (investigated by QSAR: "quantitative structure-activity relationship" study).

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Very often, ambiguities arise in deciding if two similar-looking Zhdanov symbols represent the same structure or two different structures. Starting from the concept of congruence of two structures, the effect of various symmetry operations on the crystal structure has been systematically analysed and the corresponding changes in Zhdanov symbol examined. Practical criteria have been evolved to decide quickly the congruence of two polytypic structures represented by similar-looking Zhdanov symbols. Pairs of structures in MX2-type and MX-type polytypic compounds have been identified which are fundamentally noncongruent but give !;he same set of X-ray intensities on calculation. These have been identified as first-found practical examples of homometric structures. Semi-empirical rules have been formulated to obtain theoretically an infinite number of such pairs.

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