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field MR-Linac. In addition to 4D-MRI, the high-performance architecture facilitates clinical use of other advanced MRI techniques (e.g., MR fingerprinting). Future work will focus on developments to further speed up image reconstruction.

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significant outlier was identified having mean local lung HU beyond two standard deviations from the mean of all patients. Upon removal of this outlier, "mean HU difference" (r 2 Z 0.56 e first fraction, and r 2 Z 0.56 e last fraction) and "local target contrast" (r 2 Z 0.48 e first fraction, and r 2 Z 0.40 e last fraction) were correlated with mean 3D vector difference. Three of 10 patients had inter-observer variability that was considered clinically significant, defined here as having a 95% confidence width greater than 5 mm. All of these patients had higher "target excursion" and/ or "local target contrast" scores compared to the remaining patients. Conclusion: Three metrics were shown here to potentially identify patients for which large inter-observer variations would be anticipated and may be used in the future to develop thresholds for additional interventions to mitigate these registration variations.