The house becomes one of the basic human needs after food and clothing. The quality of the house is determined by physical factors and other factors such as the socio-cultural economy of the inhabitants. Tuberculosis is one of the most infectious diseases with high mortality in Indonesia, Central Java ranks third on the national scale after West Java and East Java in 2016. Magelang has the highest new cases of tuberculosis in Central Java at 775.32 per 100,000 population in 2016 and increase case 845.4 per 100,000 population in 2017. Tuberculosis infection occurs with various factors, including physical (home), and non-physical (socio-cultural and economic) of the inhabitants. The problem is how the physical and non-physical factors of the house affect on the endemic cases of tuberculosis patients in Magelang. The purpose of the study is to examine the effect of physical and non-physical factors on the increasing cases of tuberculosis patients in Magelang. In this article, the researcher uses qualitative descriptive methods with literature review. The results of this review literature will be used to examine empirical cases in Magelang.