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The restoration of marrow in a mechanically depleted segment of rabbit femur has been reported to be a local phenomenon initiated by cells normally resident in bone. That marrow regeneration in an evacuated femur is independent of circulating stem cells has been confirmed in mice bearing a heterologous marrow transplant. Mice were given 800 R of whole-body X-radiation with experimental femur shielded. Rat marrow cells, histochemically distinguishable from those of the mouse by alkaline phosphatase staining, were then transplanted to the irradiated animals. The shielded femur diaphysis was evacuated by dextran perfusion, and 2 weeks later the animal was sacrificed. Imprints were made of the spleen and of the marrow in the contralateral limb, the epiphyseal ends of the depopulated femur, and the depopulated section of the femur. Alkaline phosphatase staining showed that all of the areas involved except the evacuated femur section had an abundance of alkaline-positive rat cells. The depopulated femur diaphysis showed a typical regenerating marrow tissue at 14 days and the cell constituents were of mouse cell origin.

A 22 year old woman with Primary Oxalosis was dialysed for four years before renal transplantation. This failed acutely from graft rejection although there was evidence of oxalosis in the graft. Dialysis was continued until the time of death a year later. Over the period of dialysis progressive and extensive osteosclerosis developed. This was confirmed at autopsy to be related to widespread oxalate deposition.

No abstract

CreatinineKinase (CK) CASE REPORTA 72 year old man with no past history of ischae.dc heart disease was admitted on 27/3/79 with low back pains following a fall down the stairs. He also noticed some terminal dribbling during micturition and a rectal examination revealed that the prostate gland felt rather hard. The provisional diagnosis was acute back strain and prostatomegaly for investigation. His back strain settled down rapidly in hospital and he was advised to have an intravenous urogram.The intravenous urogram was performed on 5/4/79 and 60 ml of sodium diatrizoate was injected intravenously over one minute. About five minutes after the injection the patient complained of coldness and shortness of breath. He was observed to be sweaty and slightly dyspnoeic. His blood pressure had dropped from a baseline of 160/100mmHg. to 100/80mmHg. He also developed generalized urticaria.Hydrocortisone 100 mg and promethazine 25 mg. were given intravenously together with intranasal oxygen. However, the patient developed a central oppressive chest pain radiating to his left shoulder and hand about twenty minutes after the injection of contrast. It was also noted that he was sweating profusely. The urogram was aban-985 140 ' Medical Registrar, Modbury Hospital. 'Senior Physician, Modbury Hospital. 'Staff Radiologist, Modbury Hospital.