Agricultural production is highly dependent on the environment and sensitive to environmental changes. During the past time, the changes in natural and socio-economic factors have strongly affected salt production. Thus, salt farmers in Can Gio, Ho Chi Minh City have put great effort into implementing various solutions to overcome the difficulties to maintain production, secure income, stabilize life and preserve traditional occupation. To have a full and systematic view on this issue, a study on the livelihoods of salt farmers in the context of environmental changes was carried out. The study used the social survey method with a sample size of 106 salt-producing households in Can Gio district. Data collection tool is a structured questionnaire and data analysis methods are descriptive and inferential statistics. Results show that salt production is a livelihood that is easily vulnerable to changes in natural and socio-economic factors. As for the natural factors, early and erratic rains are the main risk for salt production. Regarding the socio-economic factors, unstable markets, falling selling prices and increasing production costs bring many risks to salt farmers. They perceive environmental changes and their impacts on their livelihoods. The current livelihood capacities of farmers including financial, technical and institutional capacities for salt production are not high. Solutions implemented locally to deal with negative environmental impacts include adjusting production inputs, diversifying livelihoods and connecting salt production areas with consumption markets.