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SynopsisSeven (21%) of 34 patients with a severe DSM-III diagnosis of major depression had red-cell folate levels below 150 ng/ml. This subgroup with folate deficiency had significantly lower CSF 5-hydroxyindoleacetic acid (5HIAA) compared to neurological controls. For all depressed patients red-cell folate was significantly correlated with CSF 5HIAA and homovanillic acid (HVA). CSF tetrahydrobiopterin (BH4) was significantly correlated with CSF 5HIAA and HVA and red-cell folate. Our observations provide further evidence of the links between folate, biopterin and monoamine metabolism in depression.

lie for tragedieswheretherehasbeenno outreach, and previous carers may not even know about them?Conclusions from the three-year study await our final report this year. They will be based on the clinical and social outcomes, users' (patients and relatives) satisfaction, risk assessment, and an economicanalysis. MA1-r MUUEN London SE5 8AFby the fact that the point ofentry to the trial was the finding ofa low or borderline red cell folate level, at which point many of the patients were already on standardmedication. We were studyingin a placebo Gwendolen Road Leicester LE5 4PW

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