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In Experiment 1, the dopamine blockers pimozide (0.5 and 1.0 mg/kg) and spiperone (0.062 and 0.125 mglkg) suppressed the acquisition of schedule-induced drinking (a form of nonhomeostatic drinking) in rats over a 15-day chronic dosing regimen. In Experiment 2, however, the same doses ofpimozide and spiperone did not affect deprivation-induced drinking (a form of homeostatic drinking) or ad-lib drinking. These data suggest that an intact dopamine system is necessary for the development of schedule-induced drinking, and that this suppression of schedule-induced drinking was not due to a general suppression of drinking per se.

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