In an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohn's disease have a high risk of anal cancer, including perianal fistula-related cancer, and a high risk of rectal cancer.
A major human acute phase protein, the serum amyloid A protein, has been tested in vitro for its effect on lymphocyte proliferation, the formation of E-stable rosettes, as well as the growth of HeLa and MRC5 cell cultures. Serum amyloid A protein has been found to be markedly inhibitory at 30, 100, 200, and 300 micrograms/mL, and is a very potent inhibitor of in vitro biological functions.
Les auteurs tiennent à remercier Lucille Beau clet et Martine Brault pour leurs critiques pen dant la rédaction du manuscrit, de même que Silvia Vidal pour le dessin de la figure 1 et Ste phan Ruetz pour la figure 3.
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