The study provides a scientific evaluation of the biological and therapeutic properties of new topical formulation of silver sulfadiazine emulgel (1%) as an alternative for the treatment of burn wounds. The solid dispersion was prepared with poloxomer 407 by melt method and is used for emulgel formulation. The prepared silver sulfadiazine emulgel (1%) was compared with marketed silver sulfadiazine creamon healing of burn wounds in rats. Burned area evaluations on the 4th, 8th, 12th and 16th days showed statistically significant better burn wound healing in silver sulfadiazine emulgel (1%) as compared to marketed silver sulfadiazine (1%) group. Moreover, it showed no irritation when tested in rabbit skin irritation test. In conclusion, application of silver sulfadiazine emulgel may be more effective in healing burn related skin wounds in the rat model.

McCune Albright syndrome is characterized by the clinical triad of precocious puberty, polyostotic fibrous dysplasia, and café-au-lait pigmentation. Authors reported the case of a 6 years old girl presenting with vaginal bleeding. Investigations showed high serum oestrogen levels, with low FSH and LH levels. Ultrasonography revealed a multiloculated right ovarian cyst. Based on the history and investigations, the patient was diagnosed as a case of precocious puberty. In order to rule out the presence of any ovarian malignancy, tumour markers were sent and found to be within the normal range. A CT pelvis was done which revealed fibrous dysplasia of the pelvic bone. The coexistence of precocious puberty with fibrous dysplasia confirmed the diagnosis of McCune Albright syndrome.