HIV is a retrovirus which weighed down the immunity of a hale and hearty person and causes of a syndrome called AIDS that means acquired immune deficiency syndrome. AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections. HIV infects vital cells in the human immune system such as T Helper cells (CD4 + T cells mainly), macrophages and dendritic cells. HIV infection leads to low levels of CD4 + T cells through a number of mechanisms. A 43 years, male patient, sale's man by occupation, known case of retroviral disease admitted in I.P.D. of I.P.G.T. & R.A. Jamnagar, Gujarat, with the complains of loss of movement in left half of body, weight loss of 22kg., chronic cough, loss of appetite and deep pressure soars over right Gluteus medius, Constipation & diarrhoea (intermittent) since 4 years. Patient was a treated case of pulmonary Koch's with tubercular meningitis 4 years back. The patient was treated with 3 courses of Basti therapy and rejuvenating drugs. After the treatment patient's appetite improved, 12 kg weight gain, improved power grade of limbs, motor function of limbs restored partially, pressure soar absolutely healed, and improvement in total leucocytes count. As absolute cure in the AIDS patients is still an awaited destiny, but with the Panchakarma along with rejuvenating therapy, quality of life of patient improved significantly. Though there is slight improvement in CD4 count and no change in viral overload but with the given remedy, complaints and associated disability treated successfully.