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BACKGROUND AND OBJECTIVE: A computational model has predicted parameters for using a navigated microsecond pulsing laser system to treat central serous chorioretinopathy (CSC). PATIENTS AND METHODS: A prospective, single-center, interventional case series was conducted for patients with acute CSC who were enrolled following screening and informed consent. Treatment involved laser pulse duration of 50 μs, 2.4% Duty Cycle, 100 μm spot size, and 10 ms pulse duration. RESULTS: Average best-corrected visual acuity (decimal) of 12 patients improved from 0.86 ± 0.03 at baseline to 0.97 ± 0.01 at 3 months. Baseline central retinal thickness decreased from 452.58 μm ± 24.53 μm at baseline to 249.25 μm ± 2.92 μm at 3 months. Retinal sensitivity improved from 24.1 dB ± 1.09 dB at baseline to 28.98 dB ± 0.23 dB at 3 months. In all cases, subretinal fluid was resorbed. CONCLUSION: The parameter sets derived from the computer model can be applied safely and effectively for CSC treatment using the navigated microsecond pulsing laser system. [ Ophthalmic Surg Lasers Imaging Retina . 2020;51:512–520.]

The purposeis to analyze the stages of ophthalmological healthcare system’s evolution in premature children on the basis of Kaluga branch of FGAU «MNTK “Eye Microsurgery” named after acad. S.N. Fedorov».Methods. In 2003, on the basis of Kaluga branch of MNTK “Eye Microsurgery” the system of ophthalmological care for premature children had been created. The specialists of children’s ophthalmologic department of the branch had started regular field screening examinations of premature infants from risk group of ROP in neonatal care unit in 4 regions of the Central Federal district. In parallel, new diagnostic methods and technologies of laser and surgical treatment of active PH stages had been actively developed and introduced.Results. From 2003 to 2018 approaches for detection, diagnostics and treatment of ROP had been evolved substantially. At the initial stage, there were no uniform data about the optimal timing for early detection of active stages ROP, and quantitative markers of ROP progression were not determined. The effective management and treatment algorithms for the patients with active ROP had not been implemented yet. To the date vast experience had accumulated: more than 15 thousand infants with ROP risk had been screened, more than 750 on-site examinations in the neonatal care units and perinatal centers had been performed. High-tech methods of diagnostics, laser and surgical treatment of ROP had been developed and are actively used now. Multicenter clinical studies evaluating the possibilities of anti-VEGF therapy for active ROP have being performed. Over 3000 laser and more than 1.300 surgical operations for different stages of ROP had been performed.Conclusion. Many-years experience of ophthalmological healthcare system in premature children functioning have demonstrated its consistency and effectiveness. The system includes interrelated stages, providing continuity between the perinatal centers and specialized ophthalmic institution, with complying the common approaches to early screening and diagnostic monitoring, including through telemedicine, as well as technologies of laser and surgical treatment of ROP.

Purpose: to evaluate the clinical efficacy of subthreshold laser treatment of focal DME in continuous and micro-pulse modes using a navigation system based on OCT-A data.Methods. 33 patients (33 eyes) with focal DME were under observation before and after laser treatment. All patients underwent high-resolution OCT-A using the HD Angio Retina 6×6 mm protocol on RTVue-100 XR Avanti (Optovue, USA) and SOLIX (Optovue, USA) devices. The height of edema in the fovea averaged 304.5 ± 5.4 um in the group, in the area of edema outside the fovea — 336.5 ± 7.5 um. The initial best corrected visual acuity (BCVA) was 0.75 ± 0.06. The central retinal sensitivity (CRS) before treatment was 24.10 ± 0.48 dB. The treatment was carried out on the NAVILAS 577S navigation laser system (“OD-OS”, Germany). The results were evaluated within 1, 3 and 6 months after treatment.Results. 1 month after laser treatment, the average CRT in the group was: in the fovea — 294.00 ± 5.38 um, outside the fovea — 318.50 ± 6.44 um. The BCVA increased on average to 0.80 ± 0.06; the CRS to 24.65 ± 0.47 dB. After 3 months, a further decrease in the height of edema was observed (CRT in the fovea was 252.50 ± 2.19 microns, outside the fovea 280.50 ± 3.75 microns). The BCVA increased on average in the group to 0.85 ± 0.06, CRS — 25.50 ± 0.30 dB. After 6 months, the average CRT in the group was: in the fovea — 246.50 ± 1.81 microns, outside the fovea — 273.50 ± 4.56 microns. A stable increase in the BCVA indicators was achieved — 0.85 ± 0.06 and CRS — 26.65 ± 0.16 dB. At the time of 1.3 and 6 months after treatment, an increase in vascular density was observed in the deep vascular complex and the superficial vascular plexus.Conclusion. The preliminary results obtained by us indicate the effectiveness of navigation sub-threshold laser treatment of DME in the micro-pulse and continuous modes, based on targeted topographicallyoriented laser exposure according to OCT angiography.