A twelve-year-old female spayed Greyhound was presented with ulcerative nodular lesions,generalized weakness and pain. At the time of presentation, the dog was receiving prednisolonefor a presumptive diagnosis of cervical discus hernia. Fine needle aspiration of the nodular lesionsdemonstrated protozoal tachyzoites. Immunohistochemistry confi rmed the diagnosis of Neosporacaninum infection. Clindamycin therapy, together with the withdrawal of immunosuppressivemedication, resulted in complete remission. This report documents the fi rst case of cutaneousneosporosis in Belgium.