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Fused pyrimidine derivatives R 0515Synthesis Leading to Novel 2,4,6-Trisubstituted Quinazoline Derivatives, Their Antibacterial and Cytotoxic Activity Against THP-1, HL-60 and A375 Cell Lines.-Twelve 2,4,6-Trisubstituted quinazoline derivatives of type (V) are prepared and screened for their antibacterial and cytotoxic effects against the title cell lines. Derivative (Vd) exhibits the highest activity against THP-1 and HL-60 cell lines, whereas (Va) and (Vb) show moderate activity. -(CHANDRIKA, P. M.; YAKAIAH, T.; NARSAIAH*, B.; SRIDHAR, V.; VENUGOPAL, G.; RAO, J. V.; KUMAR, K. P.; MURTHY, U. S. N.; RAO, A. R. R.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 6, 840-847; Fluoroorg. Div., Indian Inst. Chem. Technol., Hyderabad 500 007, India; Eng.) -M. Bohle 43-171

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Fused pyrimidine derivatives R 0515Synthesis of Novel 4,6-Disubstituted Quinazoline Derivatives, Their Antiinflammatory and Anticancer Activity (Cytotoxic) Against U937 Leukemia Cell Lines.-Compounds (IV) show poor to moderate antiinflammatory and promising anticancer activities. Derivative (IVc) exhibits maximum cytotoxic effects similar to the standard etoposide. -(CHANDRIKA, P. M.; YAKAIAH, T.; RAO*, A. R. R.; NARSAIAH, B.; REDDY, N. C.; SRIDHAR, V.; RAO, J. V.; Eur. J. Med. Chem. 43 (2008) 4, 846-852; Univ. Coll. Pharm. Sci., Kakatiya Univ., Warangal 506 009, India; Eng.) -R. Staver 35-147

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