A proper wound bed preparation is an important factor that determines healthy healing of wounds. The TIME framework was developed as a practical tool for this purpose. Wound management classified under the Shashthi Upakramas in the Sushruta Samhita, the ancient treatise on Surgery discusses all the principles inherent in the TIME framework. It also provides unique insights like using heat for wound management. With degenerative wounds proving to be a major medical challenge it is imperative that these concepts are revisited.

Degeneration is defined as a degradation of tissues and is a substitution in the body of an inferior for a superior form of tissue. Three main pointers of degeneration (1) aging (2) disease and (3) injury were identified as the aspects requiring an in-depth study of the role of bio-energies in the process. The Ayurveda texts specifically use the terms Kshaya and Shosha interpreted as atrophy and wasting respectively. Dhatu Vikruti, the impairment of the tissues is characterized by alteration in the quality of tissue, impairment of function and also complete destruction of the original elements of tissue. An early recognition of Dhatu Vikruti is therefore necessary to help prevent degeneration of the tissue.

Regenerative medicine is primarily focussed on stem cell engineering. Traditional systems of medicine like Ayurveda which are known for their healing capabilities can offer a lot more to the science of regenerative medicine when examined with a modern perspective. The system that lays the crux of its treatment on ensuring equilibrium in the body cannot be oblivious to tissue repair, regeneration and healing that goes on naturally in the body in times of necessity like injury and disease. The fundamental principles of Ayurveda while being different from those of modern medicine can be complementary to it. Ayurveda is also a science with practices to achieve longevity of life being one of its 8 branches. It goes without saying that anti-aging therapies form important aspects of this branch. The concepts and therapies closely and remotely associated with regeneration have been examined for their strengths in potential contribution to regenerative medicine in this article.

Wounds are a primary affliction. The healing of wounds is a complex mechanism that calls for a multipronged approach. Wounds have been observed to heal faster in a moist atmosphere as compared to a dry environment. Ayurveda the ancient science of life discusses wound management in Shashti Upakramas or sixty measures. Moist wound healing as a concept has been known to Ayurveda, as is evident from the emphasis on preserving moisture for proper healing of wounds. It is also proved from the extensive use of topical emollients; especially honey, cow ghee and sesame oil. These base materials as well as the scientific principles behind their efficacy merit a relook in contemporary times.