Most of the newly invented chemical drug moieties are poorly water soluble. According to BCS classification, class II and IV drugs are considered as poorly water soluble. So enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge to formulation scientists due to their solubility criteria. Therefore many techniques are being explored to enhance the solubility of poor soluble drugs. Solid dispersion is one of the most important method for enhance the solubility (dissolution rate) and hence oral bioavailability of poorly soluble drugs. In solid dispersion the particle size of drug is reduced or a crystalline pure drug is converted into amorphous form and hence the solubility is increased. Polymer incorporating in solid dispersion technology is usually hydrophilic in nature and also showing compatibility with the drug to enhance the drug solubility. This review mainly discus about solid dispersion, preparation methods, and finally characterization.

After one hour the respective treatment 0.1 ml of 1% w/v Carrageenan suspension was injected subcutaneously into the plantar surface of the right hind paw. The paw volume was measured by using a plethysmometer immediately after 1, 2, 3, 4 h of carrageenan treatment. The anti- ABSTRACTThe anti-inflammatory activity of Vitex NegundoLinn was studied in carrageenan induced paw edema & cotton pellet granuloma in albino rats. The anti-inflammatory activity of the Ethanolic and aqueous extracts (100 & 200mg/kg) were evaluated against the carrageenan induced paw edema of rats were compared with the standard drug Indomethacin. The extract at the test doses of 100 and 200 mg/kg body weight reduced the paw edema induced by Carrageenan by 48.13% and 57.18% respectively, where as the standard drug showed 61.16. The paw edema suppressant effect was significant (P < 0.05) in the dose of 100&200mg/kg ethanol and aqueous extracts.When compared between control and two extracts, Ethanolic extract shows maximum anti-inflammatory activity. Thus it can be concluded that the extract of Vittex Negundo. Linn extract posses the anti-inflammatory activity.

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