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Background: Lymphocyte subsets play significant roles in the occurrence and progression of malignant tumors. CD3+CD4+, CD3+CD8+, CD16+CD56+ lymphocytes are important lymphocyte subsets in peripheral blood. Platinum-based chemotherapy is one of the standard treatments for advanced non-small-cell lung cancer (NSCLC). We aimed to explore the relationship between different subsets with the prognosis of platinum-based chemotherapy in advanced NSCLC.Methods: A retrospective analysis of 428 advanced NSCLC patients diagnosed from January 2015 to June 2018 received platinum-based chemotherapy was conveyed. Peripheral blood was obtained one week before treatment and lymphocyte subsets were analyzed. Receiver operating characteristic (ROC) curves were used to determine the optimal cutoff values for lymphocytes subsets, and Kaplan-Meier method and Cox regression analysis were used to evaluate their predictive effects on prognosis.

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