Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

We studied the cardioprotective effect of 2,6-diisobornyl-4-methylphenol under conditions of myocardial ischemia/reperfusion in rats. Daily administration of 2,6-diisobornyl-4-methylphenol (100 mg/kg intragastrically) over 3 days before and 5 days after modeling of myocardial ischemia/reperfusion prevented the increase in the infarction area by almost 2 times in comparison with the control by day 5 after recirculation. The type and severity of pathological changes in ECG parameters reflecting necrotic changes in the myocardium under the action of the compound significantly decreased by day 35 of the experiment. Animal survival rate during the first 24 h after ischemia/reperfusion modeling in the experimental group was by 29% higher than in the control group.

This paper focuses on the prospects for using new materials and nanotechnologies in pharmacology and pharmaceutical industry. The authors systematize science and technology priorities of the global pharmacology and determine the perquisites for the application of the technologies emerging in the production of pharmaceutical products. The study has been conducted using the method of critical technologies. The object of the study is the thematic science and technology focus area “Hybrid materials, convergent technologies, biomimetic materials and medical supplies”. Based on the findings, the authors have drawn a number of conclusions within the frameworks of the monitoring of science and technology development of priorities implemented by a network of centers for industrial foresight. Besides, the authors have analyzed the implementation of the existing approaches to the definition of critical technologies in the context of Russia’s pharmaceutical industry. Moreover, the authors have determined the conditions for application of the method of critical technologies in the Russian pharmaceutical industry based on the thematic research and development focus area “new materials and nanotechnologies”.

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