An efficient design of combined radix-2 Single path Delay Feedback (SDF)-Single path Delay Commutator (SDC)-Decimation In Frequency (DIF) algorithm is proposed in this paper which can be used in Orthogonal Frequency Division Multiplexing (OFDM) with Multiple Input Multiple Output (MIMO) applications. The MIMO-OFDM communication system has tremendous and swift growth in various applications used over last decade, especially wireless and digital communication where adaptability, reconfigurability, less chip size, hardware improvements, and lower power consumption are mandatory requirements during communication. The main aim of this structure is to improve the performance of combined Fast Fourier Transform (FFT) for the MIMO-OFDM system and also to reduce the complexity of the hardware.