Spontaneous abortion in the first trimester of pregnancy is problem among Indian women accounting for 15 to 20 percent pregnancy loss. Couples with abortion histories are probably at greater risk for cytogenetic abnormality than the couples with normal children. The abnormality associated with recurrent pregnancy loss includes translocation, inversions, recurrent aneuploidy, marker or supernumerary chromosomes, heterochromatic polymorphic etc. Hence, the present study is focused to assess the prevalence of chromosomal abnormalities among couples with repeated abortion cases. It was extrapolated that repeated pregnancy loss has was very common with abnormality in the 22p(stk+) in male.