Introduction: Inflammatory Bowel Disease (IBD) is a chronic idiopathic gut condition characterised by recurring and remitting inflammation of the colonic mucosal epithelium. Benzimidazole is a prominent and attractive heterocyclic compound with diverse actions. Although seven locations in the benzimidazole nucleus can be changed with a number of chemical entities for biological activity, benzimidazole fused with a phenyl ring has caught our interest. Methods: To find and optimize novel 1-H phenyl benzimidazole compounds with favorable physicochemical features and drug-like characteristics for the treatment of IBD, in-silico studies and in-vitro approach were used to identify and optimize these derivatives as potent inhibitors of interleukin-23 (IL-23) mediated inflammatory signaling pathway. Results and Discussion: All six compounds exhibit favorable drug-like properties with good intestinal absorption properties. Its high affinity for the target Janus kinase (JAK) and Tyrosine kinase (TYK), which is thought to be a key immunological signaling cascade in the pathophysiology of IBD, is revealed by docking studies. Conclusion: Due totheir effects on decreasing inducible nitric oxide synthase (iNOS) -derived cellular nitritre (NO) release and IL-23-mediated immune signaling by decreasing cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) activity, it's conceivable that the compounds CS3 and CS6 are better options for the treatment of IBD based on in-vitro cell line investigations.

Background: Benzimidazole derivatives are widely used in clinical practice as potential beneficial specialists. Recently, the neuroprotective effect of derivatives of benzimidazole moiety has also shown positive outcomes. Objective: To develop favourable molecules for various neurodegenerative disorders using the versatile chemical behaviour of the benzimidazole scaffold. Methods: About 25 articles were collected that discussed various benzimidazole derivatives and categorized them under various subheadings based on the targets such as BACE 1, JNK, MAO, choline esterase enzyme, oxidative stress, mitochondrial dysfunction in which they act. The structural aspects of various benzimidazole derivatives were also studied. Conclusion: To manage various neurodegenerative disorders, a multitargeted approach will be the most hopeful stratagem. Some benzimidazole derivatives can be considered for future studies, which are mentioned in the discussed articles.

Recently, several studies have been reported that nonsteroidal anti-inflammatory drugs can fight against neurodegenerative disorders by various mechanisms. Currently, available therapies of neurodegenerative disorders (NDs) provide only symptomatic relief. This is the point at which we need an alternative that acts on the root cause of disease. Parkinson’s disease and Alzheimer’s disease are the two NDs concentrated here. Since the drug profile is already known, drug repurposing is a promising technique in research, thereby reducing the cost and period effectively. Epidemiological studies on various nonsteroidal anti-inflammatory drugs (NSAIDs) showed good results, but when it came to clinical studies the results are found to be poor. Hence, it can be concluded that NSAIDs provide its neuroprotective activity on its long-term use only, as the brain accessibility of this kind of drug is poor due to its lower lipophilicity.

: The virus is an infective specialist that regularly comprises a nucleic corrosive atom in a protein coat that is too little to even think about being seen by light microscopy and can multiplicate inside the living cells of a host. COVID is a gathering of infections that can cause disease, for instance, the essential basic cold, severe acute respiratory syndrome (SARS), and the Middle East respiratory syndrome (MERS). Numerous individuals debased with the COVID-19 contamination will experience smooth coordination respiratory disease and recover without requiring the common treatment. More prepared people and those with concealed clinical issues like cardiovascular disorder, diabetes, diligent respiratory contamination will undoubtedly make certified illness. The COVID-19 disease spreads generally through dabs of spit or delivery from the nose when a debased individual hacks or sneezes, so it is critical that you in like manner practice respiratory conduct (for example, by hacking into a flexed elbow). In 2019, another contamination perceived in china specifically novel COVID disease 2019 (COVID-19) was found, and on the 11th of March 2020, COVID-19 was depicted as a pandemic sickness by the World Health Organization which is rapidly stretching out to 194 countries that incorporate Europe, North America, Asia, Middle East, Latin America, and Africa. The best way to deal with thwart and ruin transmission is to be instructed about the COVID-19 contamination, the illness it causes, and how it spreads. In this survey, we are endeavoring to focus on the drugs that are used for COVID19 and their segment of movement at present chose by different nations.