The upper limb malformations in association with congenital heart defects occurring as autosomal dominant disorder are seen in Holt-Oram syndrome. It is a very rare disorder which can be detected with early prenatal ultrasound checkups. Here we are reporting two cases of holt-oram syndrome

Auto immune encephalitis comprises an expanding group of clinical syndromes that can occur at all ages (<1yr to adult) but preferentially affect younger adults and children. The clinical presentation is variable and may be mild with only a few symptoms or mimic a psychiatric disorder with delayed diagnosis of encephalitis. More complex symptomatology may be present and it can also have a fulminant course with a fatal outcome. With early detection and immunotherapy, 80% of patients may show full recovery