No abstract

Various derivatives of 1,2-dihydro-6-(4-hydroxy-5-isopropyl-2-methylphenyl)-2-oxo-4-arylpyridine-3-carbonitrile (IVa-m) were synthesized and characterized. Their antioxidant and antimicrobial properties were evaluated by measuring their activity in vitro. Among the newly synthesized derivatives IVg, IVh, IVi, IVj, IVk, IVl, and IVm showed good antioxidant activity. However, all derivatives show better antibacterial and antifungal properties than that of parent thymol. The probable mechanism, particularly for antioxidant properties of these compounds is proposed.

A series of novel 3-methyl-N"-(2-oxoindolin-3-ylidene)-4H-benzo [b][1,4]thiazine-2-carbohyrazides have been synthesized and studied on their in vitro antimicrobial activity potency to establish structure-activity relationship. Several compounds demonstrated promising antifungal and antibacterial activity; however, other tested compounds exhibited moderate to poor antimicrobial activity with respect to the reference drug against the test strains.

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