The objective of this study is to assess the value of postcone endocervical curettage, after conization of cervical intraepithelial neoplasia or carcinoma as a predictive tool for residual lesions. This is a retrospective observational study. All data were obtained by the University Hospital of Zurich, Department of Gynaecology. One hundred fifty patients underwent hysterectomy within 12 months after conization and endocervical curettage from 1993 to 2006. To analyze the sensitivity, specificity, and the positive predictive value (PPV) and negative predictive value (NPV) of the endocervical curettage after conization, we used the Fisher exact test and (2) Methods: To analyse the sensitivity, specificity, the positive and negative predictive values of the endocervical curettage following conization we used the Fisher's exact test and Chi2-Test. The value of endocervical curettage (ECC) following conization for cervical intraepithelial neoplasia (CIN) Main outcome measures:The sensitivity and specificity as well as the positive and negative predictive values of the post-conization endocervical curettage. Results Conclusion:The endocervical curettage following conization of cervical intraepithelial neoplasia does not generally improve the prediction of residual lesions. However, in women ≥50 years, a higher specificity and positive predictive value, 0.94 and 0.88, respectively, was observed. Therefore, this subgroup of patients may benefit from an endocervical curettage.Keywords: ECC (= endocervical curettage), sensitivity, specificity, PPV (= positive predictive value), NPV (= negative predictive value)Introduction:

The concentrations of fibrin degradation products (FDP) in the urine were determined by the passive hemagglutination test in 115 patients with biopsy-proven chronic proliferative glomerulonephritis (GN), 93 patients with urinary tract infection (UTI) and 23 patients who received kidney transplants. The active GN values (12.3 µg/ml) are significantly higher than those for latent GN (0.3 µg/ml). Those for acute UTI (9.2 µg/ml) are significantly higher than for chronic UTI (1.3 µg/ml). In contrast to the reports published by others, the numerous ‘false-positive’ and ‘false-negative’ values make diagnosis of the activity questionable. Prognostic value can be expected in GN with the nephrotic syndrome (NS): patients with steroid-sensitive NS excrete no FDP and patients with steroid-resistant NS excrete larger quantities of FDP. We have confirmed that a rise in the urinary FDP level in transplantation is indicative of rejection. However, since 10 of 27 rejections were FDP-negative, the absence of FDP in the urine does not preclude rejection.

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