Movoflex® Soft Chew (Virbac, USA) is a nutritional supplement to support dogs’ mobility. It contains a unique combination of five ingredients: eggshell membrane, hyaluronic acid (HA) of high molecular weight, Boswellia serrata extract, astaxanthin, and vitamin D3. Krill oil and low molecular weight HA are now added to the supplement. The tolerance of this advanced formula was first evaluated in dogs. The aspect, palatability of the chew, and effectiveness on mobility criteria were then assessed by sixty-nine dog owners who were regular users of the current Movoflex® Soft Chews. The chew was found to be well-tolerated and similar in terms of aspect and acceptability to the current one. All but one mobility criteria significantly improved after 30 days, including the ability to walk, climb, stand, interact with people, or the way of walking.