The aim of this study is to investigate anticancer activity of methanol extract (ethylacetate, n-buthanol and water partitions) and water extract from Sarang semut (local name), Myrmecodya pendens which is one of Rubiaceae family. Within Papua area (Indonesia), this medicinal plant has been used traditionally as alternative treatment for ulcer, tumor and cancer. In this study, the extracts of this plant were tested for their activities in some cancer cells (HeLa and MCM-B2 cell). The result showed that water extract of this plant has better anti cancer activity compared to other extracts. The IC50 value of water extract A is 27.61 ppm (HeLa) and 54.57 ppm (MCM-B2), while water extract B is 29.36 ppm (HeLa) and 74.20 ppm (MCM-B2). Our study concluded that polar extract (water) exhibited higher anticancer activity than non-polar extracts (ethylacetate and n-buthanol).

Isolation, purification and identification of two hydrochalcone compounds from Indonesian medicinal plant "Sirihhutan", Piper aduncum (Piperaceae) had been done. Isolation and purification of ethylacetate extract subjected to column chromatography (SiO 2 ; (i).n-hexane-ethylacetate = 10:1 ~ 1 : 1; ethylacetate (ii).n-hexaneethylacetate = 8: 1 gave two pure compounds. Based on infra red, 1D & 2D-NMR, mass spectral data and comparison chemical shift of protons and carbons, the isolated compounds are 2',6'-dihydroxy-4'-methoxy dihydrochalcone and 2',6',4-trihydroxy-4'-methoxy dihydrochalcone with free radical scavenging inhibitionvalues are 21.77 % and 90.1 % respectively.

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