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Six new sesquiterpene dilactones-mikanolide, dihydromikanolide, scandenolide, dihydroscandenolide, deoxymikanolide, and miscandenin-have been isolated from above-ground parts of Mikunia scandens (L.) Willd. The first five are germacranediolides whose structure and stereochemistry were determined by a combination of chemical methods and nmr techniques and by correlation of deoxymikanolide with the germacranediolide isabelin. Miscandenin is an elemanediolide containing a dihydrooxepine ring, whose formation can be rationalized as involving the Cope rearrangement of a 1,lO-deoxymikanolide precursor.