Summary. Inguinal hernioplasty is the most frequently performed surgical operation in the world, but the level of complications still reaches 11 % and of recurrences — 5 %. According to some authors, the reason may be in chronic inflammatory changes of the hernia sac and perihernial tissues. Aim. To study the pathohistological changes of the hernia sac and perihernial tissues of patients with inguinal hernias for development of adequate methods of complications prophylactics. Material and methods. The pathohistological examination of fragments of hernial sac and perihernial tissues of 24 patients with groin hernias was performed. Results and discussion. The investigation detected the signs of chronic inflammation in fragments of tissue of hernial sac in all patients. In 8 (33,3 %) patients the signs of inflammation were found only in fragments of hernial sac, and in 16 (66,7 %) – they were combined with the inflammation of perihernial tissues. Among them, the pronounced signs of chronic inflammation were found in 6 (25,0 %) patients with recurrent groin hernias, they were combined with the pronounced scarring changes of hernial sac and perihernial tissues. Conclusions. 1. Chronic inflammatory changes of the hernia sac and perihernial tissues are among the reasons for the development of postoperative complications and recurrences. 2. An important component of prevention of complications can be use of antibacterial and anti-inflammatory drugs.

Summary. Introduction. Abdominal sepsis (AS) is the most serious complication of inflammatory processes in the abdominal cavity, characterized by high mortality and morbidity. Violation of hemostasis is one of the key components of the pathogenesis of sepsis. Goal. Establishing the pattern of violations in the system of thrombocyte-vascular hemostasis in patients with abdominal sepsis in the postoperative period, as a prerequisite for the occurrence of adhesions. Materials and methods. The study covers observation of 52 patients with various forms of AS, aged 18-69 years (41.93±3.47). The control group consisted of 17 patients who underwent planned surgical interventions not related to the peritoneal cavity. The dynamics of the content of soluble fibrin-monomer complexes, prostacyclin and thromboxane were determined by the content of their stable metabolites in the blood. Results and discussion. Probable correlative dependences between the content of fibrin-monomer complexes in the blood and the concentration of TxB2 (positive correlation) and the level of prostacyclin in the blood plasma (negative relationship) were revealed. Identified violations in the system of primary hemostasis in patients with AS indicate the need for active correction of changes in thromboxane-prostacyclin systems in order to prevent thrombotic postoperative complications of a septic nature. Conclusions. Identified violations in the system of primary hemostasis in AS already on the first day after surgery indicate the need for active correction of changes in thromboxane-prostacyclin systems in order to prevent thrombotic postoperative complications of a septic nature. Taking into account the high risk of adhesion formation due to inflammatory processes of the peritoneum, it is advisable to consider the identified violations of primary hemostasis as a factor in the pathogenesis of adhesion disease.