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Summary: Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH‐I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH‐I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH‐I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.

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