Histoplasmosis is considered to be rare in India. Adrenal involvement is common in disseminated disease but may be the only site of demonstrable disease sometimes. We describe the case of a 36-year-old lady with type 2 diabetes mellitus who presented with adrenal insufficiency in whom computed tomography and fine needle aspiration cytology helped in establishing the diagnosis. A high index of clinical suspicion and appropriate use of invasive diagnostic methods will be helpful in early diagnosis and institution of appropriate treatment.